Stability of recent and remote contextual fear memory
نویسندگان
چکیده
منابع مشابه
Stability of recent and remote contextual fear memory.
Following initial encoding, memories undergo a prolonged period of reorganization. While such reorganization may occur in many different memory systems, its purpose is not clear. Previously, we have shown that recall of recent contextual fear memories engages the dorsal hippocampus (dHPC). In contrast, recall of remote contextual fear memories engages a number of different cortical regions, inc...
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Introduction: Previous studies have demonstrated that the &beta-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength o...
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It has been suggested that memories become more stable and less susceptible to the disruption of reconsolidation over weeks after learning. Here, we test this by targeting the anterior cingulate cortex (ACC) and test its involvement in the formation, consolidation, and reconsolidation of recent and remote contextual fear memory. We found that inhibiting NMDAR-NR2B activity disrupts memory forma...
متن کاملpropranolol–induced impairment of contextual fear memory reconsolidation in rats: a similar effect on weak and strong recent and remote memories
introduction: previous studies have demonstrated that the &beta-adrenergic; receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. there are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. in this study, we investigated the ability of the age and the strength ...
متن کاملExtinction after retrieval: effects on the associative and nonassociative components of remote contextual fear memory.
Long-lasting memories of adverse experiences are essential for individuals' survival but are also involved, in the form of recurrent recollections of the traumatic experience, in the aetiology of anxiety diseases (e.g., post-traumatic stress disorder [PTSD]). Extinction-based erasure of fear memories has long been pursued as a behavioral way to treat anxiety disorders; yet, such a procedure tur...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2006
ISSN: 1072-0502
DOI: 10.1101/lm.183406